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KMID : 0043320160390081137
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Archives of Pharmacal Research
2016 Volume.39 No. 8 p.1137 ~ p.1143
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Attenuation of Aβ toxicity by promotion of mitochondrial fusion in neuroblastoma cells by liquiritigenin
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Jo Doo-Sin
Shin Dong-Woon
Park So-Jung
Bae Ji-Eun
Kim Joon-Bum
Park Na-Yeon
Kim Jae-Sung
Oh Jeong-Su
Shin Jung-Won
Cho Dong-Hyung
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Abstract
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Mitochondrial dynamics control mitochondrial morphology and function, and aberrations in these are associated with various neurodegenerative diseases including Alzheimer’s disease and Parkinson’s disease. To identify novel regulators of mitochondrial dynamics, we screened a phytochemical library and identified liquiritigenin as a potent inducer of mitochondrial fusion. Treatment with liquiritigenin induced an elongated mitochondrial morphology in SK-N-MC cells. In addition, liquiritigenin rescued mitochondrial fragmentation induced by knockout of mitochondrial fusion mediators such as Mfn1, Mfn2, and Opa1. Furthermore, we found that treatment with liquiritigenin notably inhibited mitochondrial fragmentation and cytotoxicity induced by Aβ in SK-N-MC cells.
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KEYWORD
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Mitochondria dynamics, Fusion/fission, Liquiritigenin, Amyloid beta
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